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A smaller number are genuine red flags that need same-day medical attention: acute pancreatitis, gallbladder disease, severe allergic reactions, acute kidney injury from dehydration, NAION (a rare vision disorder), and in people with Type 2 diabetes, hypoglycemia when combined with insulin or a sulfonylurea

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There's no predicting which direction the medications will go, and it depends both on the specific medication and the individual