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However, there are risks and side effects associated with any medication, and phentermine-topiramate risks include but are not limited to: Mood swings or irritability Trouble going to the bathroom (constipation) Possible dependency Dry mouth Troubles falling or staying asleep Numbness in the hands and feet Irregular heartbeat Headaches Increased blood pressure Seizures (rare) These risks are rare, and working with medical professionals can help manage any side effects

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The TSA was performed with TSA software (Centre for Clinical Intervention Research Department, Copenhagen, Denmark)