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Description

Compared to healthy controls, those with NAFLD who were not obese had statically elevated levels of glutamate, isoleucine and valine, while those with NAFLD who were obese had significantly elevated levels of glutamate, all BCAA, and significantly lower levels of glycine and serine

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19 Following further translocation to the mitochondria, activated phosphorylated JNK initiates a cascade in which JNK binds to the outer mitochondrial membrane scaffold protein Sab, inhibiting electron transport and thereby increasing the generation of ROS and peroxynitrite

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