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1 Model based estimates based on an analysis of covariance model including treatment and type 2 diabetes status as factors and baseline value as a covariate 2 Not included in the pre-specified hierarchical testing 3 Model based estimates based on a mixed model for repeated measures including treatment and type 2 diabetes status as factors and baseline values as a covariate 4 Baseline value is the geometric mean 14.3 Weight Reduction and Long-Term Maintenance Study in Pediatric Patients Aged 12 Years and Older with Obesity SPL UNCLASSIFIED SECTION Overview of Clinical Trial in Pediatric Patients WEGOVY was evaluated in a 68-week, double-blind, randomized, parallel group, placebo-controlled, multi-center trial in 201 pubertal pediatric patients aged 12 years and older with BMI corresponding to 95th percentile standardized for age and sex (Study 7) (NCT#04102189)

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Some studies have reported that knockdown of GLP-1R in Sim1 neurons did not affect body weight, body composition, or food intake, nor did it significantly change the anorexic effects induced by i.p

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