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This allows users to choose the right strength and release profile based on their specific needs
Consequently, BCL-2 family inhibitors have been identified to function as senolytics, including ABT-737, ABT-263 (Navitoclax), A-1331852, and A-1155463
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Delivery of synthetic miR-132 restores hippocampal neurogenesis and cognitive function by reducing A burden and tau hyperphosphorylation, whereas intracerebroventricular administration of anti-miR-132 oligonucleotide abolishes the exercise-induced benefits on neurogenesis, cognition, and BDNF expression [103, 104]
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