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Diabetes Care (2021) 44:143342

TGF-1 combined with IL-1 (TGF-1 + IL-1) was applied to induce fibroblast activation in vitro

A less common but possible side effect, due to its breakdown into trimethylamine

That foundation is the 40:1 myo-inositol to D-chiro-inositol ratio, which has direct PCOS RCT evidence behind it for ovulatory function and insulin sensitivity (Nordio & Proietti 2012