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The mature HGF protein binds to its high-affinity receptor c-MET, leading to its activation and phosphorylation of multiple serine and tyrosine residue sites
These agents act more specifically, which lowers side effects and improves patient outcomes
In ovarian cancer cell lines SKOV-3 and OVCAR-3, Ex-4 induces apoptosis by modulating NF-B downstream targets, including matrix metalloproteinase-9 (MMP-9), intercellular adhesion molecule-1(ICAM-1), BAX, Bcl-2, and cyclin D [68]
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