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J Ophthalmol 2019(1):1429548 Chung MY, Epperson BK, Chung MG (2003) Genetic structure of age classes in Camellia japonica (Theaceae)

The stomach-empty requirement means the medication is present in the GI tract during the absorption phase, which can cause localized irritation that injectable forms avoid

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So, combining them can make side effects like dizziness, sleepiness, and confusion worse