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First, using HPLC and HPLC-associated radioactive detector, we identified six radioactive components, in addition to prototype [ 3 H]BPC157, in rat plasma collected at 0.05, 0.167, 1, 8, and 24 h after administration (Supplementary Figure S1)
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Depot formulations : Encapsulating peptides in biodegradable polymer microspheres (e.g., PLGA) creates slow-release formulations that can extend effective duration to months, regardless of the peptide's intrinsic half-life
Inflammation- and stress-response signaling research : Investigators track pathway markers, mediator expression, or tissue-response profiles in model systems that may include BPC-157 as a probe
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