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While the origins of the observed differences between mice and humans with respect to the l-carnitineBBTMATMAO pathway are not clear, the fact that the second reaction in the conversion of l-carnitine into TMA (i.e., BBTMA) showed marked induction with dietary exposure in subjects likely plays a major role in the observed differences

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First, this analysis was based on aggregated arm-level data rather than individual participant data, which limited the ability to adjust for patient-level heterogeneity, including comorbidities and concomitant therapies

[27] Canagliflozin is the first SGLT2 inhibitor to be approved for use in the United States