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In the 72-week non-diabetic obesity trial, adults lost -15.0% at 5 mg, -19.5% at 10 mg, and -20.9% at 15 mg. Real-world outcomes vary because dose reached, adherence, and baseline state vary
individuals with active cardiovascular disease, active or prior malignancy, or who are pregnant or breastfeeding should avoid this combination
Animal doses are calculated per kilogram of body weight and do not scale linearly to humans
Oral administration, however, faces significant hurdles due to digestive breakdown, substantially reducing absorption
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