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However, given the similar clinical efficacy and safety profiles amongst the available agents within the DPP-4 class of medications, the published head-to-head trials reviewed in this manuscript represent a good comparison of the two classes of medications (26, 35)

This increased transmission of pulsatile and high-pressure blood flow into the cerebral circulation is associated with cerebral microvascular damage, which contributes to chronic reductions in CBF seen with aging and disease (Suri et al., 2020)

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"Combination approaches to obesity pharmacotherapy: Rationale and emerging evidence." Obesity Reviews , 25(2), 134-148