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To our knowledge, this is the first study of its kind to utilize network pharmacology to identify genes which are associated with epilepsy, are potential targets of the ASMs CBZ and VPA, and are also involved with oxidative stress, to identify proteins of which specific oxidative stress pathways are induced due to CBZ and VPA treatment in epilepsy therapy
Tulsi is also known to have numerous pharmacological activities, such as antidiabetic, antistress, immunomodulatory, analgesic, antipyretic, anti inflammatory, antiulcerogenic, antihypertensive, CNS depressant, hepatoprotective, radioprotective, antitumor and antimicrobial activities
Some studies suggest that NSAIDs can interfere with mitochondrial function, leading to an increase in reactive oxygen species (ROS)unstable molecules that contribute to oxidative stress
Dosing, route, and duration should align with individual oxidative stress markers and metabolic goals
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