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Rather than conducting a new meta-analysis, the authors synthesize findings from major randomized clinical trials, highlighting outcomes related to glycated hemoglobin (HbA1c), body weight reduction, major adverse cardiovascular events (MACE), and kidney function decline as reported in large cardiovascular outcomes trials (CVOTs), obesity randomized controlled trials, and early-phase clinical development studies
These figures summarise how FOXO4-DRI is commonly described in research literature and supplier documentation
LY3463251 is the first GDF-15 agonist that has completed a phase 1 clinical trial WL was 3% after a 12-week treatment period [100]
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