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This is as much as 6 times the upper limit recommended, which makes the risk of diarrhoea as a side-effect a distinct possibility

These are produced by our healthy gut bacteria

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Initially described as a mediator of exercise-induced browning of white adipose tissue and increased energy expenditure, irisin was proposed as a candidate exercise- associated signaling molecule ( Subsequent debate regarding assay specificity, circulating concentrations, and translational relevance led to skepticism regarding irisins role in humans