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Importantly, the overwhelming majority of systems reviewed achieved significant reductions in cardiotoxicity as doxorubicin's most serious dose-limiting adverse effect while maintaining or improving antitumor efficacy, validating the core premise that nanocarrier-mediated delivery can fundamentally improve the therapeutic index of this cornerstone anthracycline agent [200]
(PubMed) Madigan SM, Tracey F, McNulty H, et al
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