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Chronic sleep disruption is associated with lower Akkermansia muciniphila populations in the gut microbiome, which creates a double hit, reduced GLP-1 sensitivity plus reduced microbial GLP-1 stimulation

Anti-adipogenic effects were also seen under high glucose conditions [23]

Ten operant conditioning boxes (30 25 30 cm, Coulbourn Instruments, USA) were utilized, each equipped with two nose-poke holes on one side and controlled by Graphic State Notation four software (Coulbourn Instruments, USA)