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In addition, cross-breeding ALS-transgenic mice with ARE-human placental alkaline phosphatase (hPAP) reporter mice allowed to reveal that Nrf2 activity was more intense in skeletal muscle than in the spinal cord, and evident since before motor symptom onset [264]
For individuals with liver diseases such as Primary Biliary Cholangitis (PBC), it may help maintain healthy liver function and slow disease progression
Amchova and Ruda-Kucerova, 2023
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