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Most authors believe the primary mechanism is still telogen effluvium from rapid weight loss, potential calorie or protein deficiency, and the overall metabolic shock to the body rather than the GLP-1 molecule directly attacking the hair follicle
Secondary endpoints in trials include reductions in waist circumference , visceral fat mass, appetite scores, and daily caloric intake
Targeting this intersection could offer dual benefits
In a research context, it is useful as: A non-selective reference molecule in melanocortin pharmacology, for characterizing receptor selectivity of new analogs A tool compound for studying melanogenesis in vitro and in vivo A model molecule for studying MC4R-mediated effects on appetite and libido A comparator molecule in the development of newer selective agonists In the cosmetic underground, Melanotan II is used off-label as an injectable tanning peptide
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