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If you don't lose 5% of your weight after 12 weeks of taking Contrave, your doctor may tell you to stop taking it because it's unlikely to work for you, the FDA says

Small number of research groups : A limited number of research groups have conducted most studies, which may affect the generalizability of the results

Your initial intake and review take longer

Low B12 levels are associated with symptoms like: Fatigue or low energy Difficulty concentrating Numbness or tingling in hands and feet Swollen, inflamed tongue Dizziness or unsteadiness Muscle weakness Vision problems like blurriness or double vision What are the possible B12 injection side effects