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and Boretto et al

The most common type of hyperpigmentation issues seen in clinic are: Sun damage hyperpigmentation (sunspots or solar lentigines): Over time as our skin is exposed to UV and even blue light from the sun and other sources, the melanocyte cells start to become damaged themselves, causing them to be less able to regulate the production of melanin

Generally, these variation peptides are found in parts per million in active technologies that topical products claim to include at high percentages but the final concentration of the variation peptides in topical products is generally less than 0.01% and these peptides would then have to be converted to even smaller amounts of pure copper peptides within the skin

Neuroinflammation 10:4