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Concentrations above are arithmetic, not dosing guidance
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Thus suggesting a specificity for IGF-1R
Although to our knowledge, there is no direct evidence of crosstalk between the GDH pathway and the GABA shunt, we speculate that the GDH pathway may interfere with the decarboxylating step of the GABA shunt by controlling the available glutamate via the action of Gdh1, Gdh2 and Gdh3 proteins under specific conditions
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