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Consequently, there is a necessity to design compounds capable of irreversibly targeting and blocking ASCT2 transporter proteins
Tumor cells form a two-way connection with circumferent stroma in the early stage of invasion and after that, tumor-stroma interaction helps the tumor to develop toward metastasis ( Pre-Metastatic Niche An appropriate microenvironment, namely, pre-metastatic niche, can be established in secondary tissues and organs before metastases occurring through a complicated mechanism by interaction between the primary tumors and organs stromal components (92)
Deng Y, Jiang S, Huang Y, Tan X, Huang Y, Chen L, Xu J, Xiong X, Zhou J, Xu Y
Clin Cancer Res (2014) 20(12):30717
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