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According to the working model, these cysteine residues may undergo chemical modification/remodeling including trisulfide bond formation and/or related reactions, resulting in a regional (minor, but effective) structural alteration that enhances c-met binding and the nitration resistance of Y198-HGF

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Gradual escalation over 16 to 20 weeks is the standard clinical protocol precisely because it minimizes GI symptoms while still reaching a therapeutic dose