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10.1016/S0272-6386(03)00113-6 50
In these studies, amphetamine was given in consecutively higher doses until psychosis was precipitated, often after 100300 mg of amphetamine
Multiple cellular processes are considered to contribute to this functional decline and these are collectively referred to as the hallmarks of aging and these include processes like genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis 1
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