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Importantly, this was the case also for acetyl-carnitine, which is synthesized in the muscle from carnitine and acetylCoA when mitochondrial acetylCoA is abundant and exceeds its usage by the tricarboxylic acid (TCA) cycle
The addition of glucagon receptor modulation to dual agonism provides additional metabolic benefits, including enhanced energy expenditure and improved fat burning, that translate into superior weight loss outcomes
Gastrointestinal side effects were mild to moderate, and no patients stopped treatment due to tolerability issues
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