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A few of the most significant contributors to NAD+ depletion include: CD38: An enzyme that breaks down NAD+ and becomes more active with age, especially in response to inflammation
NNMT is an enzyme that methylates nicotinamide, a key NAD+ precursor, depleting cellular methyl donor pools and influencing both NAD+ availability and broader methylation pathways
Contraindications: Sensitivity to the listed ingredients
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