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The primary actions are to regulate insulin and glucagon secretion only when plasma glucose exceeds normal fasting levels
In the musculoskeletal system, Chen et al
The clinical data, dosing, and labeling are tailored respectively by the FDA for their specific purposes
Second, by avoiding high peak concentrations followed by deep troughs, once-daily dosing may reduce the Cmax-related gastrointestinal side effects (nausea, vomiting) that are often associated with bolus-like GLP-1 exposure while maintaining sufficient trough concentrations for efficacy
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