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However, it is encouraging that preclinical and early human studies suggest that GLP-1 agonism appears broadly protective: indeed clinical trials of these agents are being initiated in cardiovascular disease (SELECT and SOUL trials, see below), NASH, and neurodegeneration (Alzheimers and Parkinsons)
However, the underlying molecular mechanisms remain poorly understood
These investigations continue to contribute valuable knowledge regarding peptide-mediated biological processes and molecular signalling mechanisms
Carbonyl stress induces hypertension and cardio-renal vascular injury in Dahl salt-sensitive rats
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