While there is a common claim that malate may offer a synergistic effect with L-citrulline, there is absolutely no evidence that malate offers any benefits on its own or in combination with citrulline [2]
Recent innovations include stealth nanoparticles with PEGylated surfaces that shed their protective layers upon FR binding, further enhancing intracellular drug release
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(4) M Alba, D Fintini, A Sagazio, B Lawrence, et al (2006) Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse American Journal of Physiology, Endocrinology & Metabolism, 2006 Dec, Volume 291 (Issue 6), Pages E1290-4