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Machine learning algorithms with network-based computational models for example can be applied to search for response patterns among specific natural supplements in a broadly-based patient population, forecast synergy or antagonism of action with contemporary standard therapies and stratify patients according to molecular/metabolic signatures as the basis of a precision nutraceutical oncology

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Interestingly, in trajectory 3 after 750 ns, the dynamic ECD moves back toward the TMD and is stabilized in a conformation that forms contacts mainly with ECL1, resembling the closed ECD conformation in the crystal structure

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