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NO exposure oxidizes the cobalt ion in Vit B12 from its +1 to +3 oxidation state, irreversibly inactivating the molecule (Garakani et al., 2016)
For redox metabolism we investigated total (tGSH) and free (fGSH) reduced glutathione, oxidized glutathione (GSSG), the total and free glutathione redox ratios, total cysteine, glutamyl-cysteine and cysteinyl-glycine
Contraindications include active malignancy, uncontrolled diabetes, pregnancy, or history of certain cancers
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