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It often supplements (rather than replaces) other therapies
If increased intraocular pressure is not corrected, it can lead to vision loss over time, often beginning with peripheral vision
Activated microglia release nitric oxide and other mediators that, when combined with superoxide, form peroxynitrite, a highly reactive species capable of damaging proteins, lipids, and DNA
Heerspink HJL, Sattar N, Pavo I et al (2022) Effects of tirzepatide versus insulin glargine on kidney outcomes in type 2 diabetes in the SURPASS-4 trial: post-hoc analysis of an open-label, randomised, phase 3 trial
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