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Common Side Effects of Semaglutide Use These are the most frequently reported side effects and usually decrease as your body gets used to the medication: Gastrointestinal Issues: Nausea Vomiting Diarrhea Constipation Abdominal pain Appetite Changes: Reduced appetite Changes in taste Fatigue: Feeling tired or fatigued Headache: Mild to moderate headaches Less Common Side Effects These side effects are less common but may still occur: Dizziness: Feeling lightheaded or dizzy Hypoglycemia (Low Blood Sugar): Especially when used with other diabetes medications like insulin or sulfonylureas Symptoms include shakiness, sweating, and confusion Injection Site Reactions: Redness, swelling, or itching at the injection site Rare but Serious Side Effects Pancreatitis : Inflammation of the pancreas Symptoms include severe abdominal pain that may radiate to the back, nausea, and vomiting Gallbladder Problems: Such as gallstones or cholecystitis (inflammation of the gallbladder) Kidney Problems: Worsening of kidney function Allergic Reactions: Rash, itching, swelling, severe dizziness, or trouble breathing Thyroid Tumors: In animal studies, semaglutide has been associated with thyroid tumors, including cancer