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The remaining 50% of drugs are metabolized by six additional enzymes: CYP2D6 metabolizes 20%, CYP2C9 and CYP2C19 together another 15%, and CYP1A2, CYP2A6, CYP2B6, and others metabolize the remaining 15%
The more relevant research question is whether triple receptor agonism (GIP + GLP-1 + glucagon) combining elements of both approaches could outperform either dual agonist
Rather than focusing on a single pathway, current studies explore how the peptide interacts with multiple biological systems under controlled laboratory conditions
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