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Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells

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In uveitis, chronic ocular inflammation elevates cytokine (IL-6, TGF) and matrix metalloproteinase (MMP-2 and MMP-9) levels, which collectively degrade the capsular basement membrane, stimulate LEC proliferation, and promote EMT (134138)

To investigate the ability to generate a therapeutic effect, the multicellular tumor spheroids were treated with Ru(II)-OH, NP2, or NP4 (10 M Ru) in a 1% or 21% O 2 atmosphere and afterward incubated with a cell live or death stain