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Among the systems of retinal cells to mitigate ROS and manage oxidative stress, a principal one is glutathione (GSH), and it relies on nicotinamide adenine dinucleotide phosphate (NADPH) 1
Standard pharmacology says steady state arrives after roughly four to five half-lives, so about four to five weeks of consistent tablets, and blood levels early in that window are well below where they will settle
However, early-stage degradation is invisible, so visual inspection has limitations
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