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When B12 levels become problematic: High-dose supplementation (particularly doses exceeding 1,000 micrograms daily) Frequent B12 injections without medical supervision Underlying conditions affecting B12 metabolism Concurrent use of multiple B12-containing supplements The NHS does not set an upper safe limit for vitamin B12 because harmful effects from excessive intake have not been definitively established
This specific enzyme acts as a biochemical bridge, driving what scientists call the "remethylation pathway" within the broader methylation cycle
Discomfort is brief and typically mild
some may trial high-dose oral with close monitoring (NHS)
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