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We chose (EAAAK) 3 rigid helical linkers to work because we believe their rigidity allows for the separation of the protein domains and improves the functionality of individual domains 58,59 when compared to flexible linkers, which appear to be suitable for linking normally connected domains in a single genetic construct, such as antibody domains in scFvs 60
However, patients with DM who have related symptoms may show normal or rapid GET without symptoms, making the association between GI manifestations and GET ambiguous
Eckel RH, Depner CM, Perreault L, Markwald RR, Smith MR, McHill AW, et al
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