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The mean (SD) absolute weight loss from the index date to the end of follow-up was 14.6 (9.9) kg in the semaglutide 2.4 mg cohort and 17.2 (11.7) kg in the tirzepatide cohort, which represented a mean (SD) percent weight loss of 14.1% (9.6) and 16.5% (10.8), respectively

While further research is needed, liraglutide may work through various mechanisms, such as reducing inflammation in the brain, lowering insulin resistance and the toxic effects of Alzheimers biomarkers amyloid-beta and tau, and improving how the brains nerve cells communicate. Edison added that those in the study who received liraglutide had nearly 50% less volume loss in several areas of the brain, including frontal, temporal, parietal and total gray matter, as measured by MRI

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