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Another study also demonstrated that lactate, produced under hypoxic conditions in colorectal cancer (CRC), promotes the lactylation of H3K18, which in turn induces the transcription of autophagy enhancer protein RUBCNL, then promotes the maturation of autophagosomes, and mediates the recruitment of class III phosphatidylinositol 3-kinase(PI3K) complexes, thereby promoting tumor proliferation and mediating tumor resistance to bevacizumab [33]

However, -tocopherol supplementation did not affect scores on the Alzheimers Disease Assessment Scale and the Mini-Mental State Examination, which in part involve assessment of memory performance (122)