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Skeletal outcomes For children specifically, any utilization of supplementary selenium compared with placebo or not might be associated with a significant lower risk of Kashin-Beck disease, an endemic osteoarthropathy with ambiguous etiology, by approximately 87% (RR: 1.88, 95% CI: 1.51, 2.33) with no heterogeneity identification (41)

It is important to note that current in vitro redox cycling detection is centred on indirect quantification of H 2 O 2 production and O 2 consumption rather than direct measurement of dynamic radical species over time 22,28

Nicotinamide and allopurinol seem to be effective in reducing the inflammation of soft tissue but the data sustaining this conclusion were obtained in a rather small sample of GO patients affected with both moderate-to-severe and mild GO ( in vitro results on the use of pentoxifylline are promising, but clinical studies provided conflicting results ( in vitro findings reported above, one can speculate that quercetin and -carotene might be the most promising, but clinical trials are needed to confirm this hypothesis