Taken together, the figure highlights a key mechanistic principle underlying the therapeutic rationale for multi-agonist strategies: while GLP-1R monotherapy achieves meaningful metabolic and hepatic benefits exclusively through indirect, systemic pathways, the addition of GIPR and - most importantly - GCGR co-agonism introduces complementary and increasingly direct hepatic mechanisms, providing the pharmacological basis for the superior efficacy observed with dual and triple agonists in MASLD/MASH
Some may benefit from weekly sessions, while others may need them less frequently, such as once a month
Sakamoto K, Yonoki Y, Kuwagata M, Saito M, Nakahara T, Ishii K (2004) Histological protection against ischemia-reperfusion injury by early ischemic preconditioning in rat retina
Definitely want to clean out the bottles after an hour, the formula will get crusty and stick to the sides