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The DAPA-CKD (Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease) trial specifically included patients with chronic kidney disease with or without diabetes to receive dapagliflozin and found that these patients experienced a lower risk of ESRD, GFR decline of at least 50%, or death from renal or cardiovascular causes in comparison to placebo [31]

That reality excluded patients who couldnt or wouldnt self-inject, regardless of how much they might have benefited from treatment