semaglutide and suicide risk Glucagon-like peptide-1 receptor agonists of suicidality among patients with type 2 diabetes: active comparator, new user cohort study No link between Ozempic, Wegovy

Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society 39(5):676679 Olloquequi J, Cornejo-Crdova E, Verdaguer E, Soriano FX, Binvignat O, Auladell C, Camins A (2018) Excitotoxicity in the pathogenesis of neurological and psychiatric disorders: therapeutic implications

Summary: Eating too much on Ozempic can occur due to psychological eating patterns, habitual behaviours, insufficient dosing during titration, rapid eating, or calorie-dense food choices that override the medication's appetite-suppressing effects

However, several factors could accelerate a reversal: declining GLP-1 drug prices through manufacturer competition or government negotiation, improved adherence data from newer formulations, long-term outcomes studies demonstrating cardiovascular benefit that changes the cost-benefit analysis, and state legislative mandates requiring obesity treatment coverage

PGC-1 is a master transcriptional co-activator of numerous genes involved in mitochondrial biogenesis