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Important precautions include: Both medications should be used with caution in people with a history of pancreatitis No routine dose adjustment is needed for Trulicity in renal impairment, but insulin requirements may be reduced with declining renal function and need individualised titration [7] [9] Trulicity may increase heart rate slightly in some individuals Maintain hydration, especially during illness

Taking too much Victoza may cause severe nausea, severe vomiting, and low blood sugar (hypoglycemia)

19 (7):582-590 Corresponding authors: Suowen Xu, PhD or Jianping Weng, MD, PhD, E-mail: sxu1984

We need better evidence on how these medications work and what to do after stopping, such as how to transition care and what kinds of lifestyle and psychological support help to maintain benefits. The new research comes at a time when access to, and interest in, weight-loss medications is rapidly expanding across the globe