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Retatrutide is still being studied, so we only have certain milestones from earlier phase 2 trials

The Ramp-Up: The dosage for both medications is gradually increased over several months (called titration) precisely to minimize side effects

Front Neurosci 14:599646 Meloni A, DeYoung M, Lowe C, Parkes D (2013) GLP-1 receptor activated insulin secretion from pancreatic -cells: mechanism and glucose dependence

The diabetes titration schedule (SUSTAIN protocol) The SUSTAIN trial program (Sorli et al., Diabetes Care , 2017) used a faster titration schedule because the primary endpoint was glycemic control, not weight loss, and HbA1c responds faster than adipose tissue