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These activities could be aggravated by MCT1 inhibition, accompanied by cytokine production, infiltration of inflammatory adipose tissue macrophages (ATMs), and the emergence of insulin insensitivity in nearby tissues [144]

In addition, there was evidence of a significant reduction in average loop diuretic dose, a lower likelihood of diuretic treatment escalation, and a greater likelihood of diuretic treatment de-escalation with semaglutide versus placeboparameters that indicate disease-modifying effects of semaglutide, and are associated with better long-term clinical outcomes in this patient population. Photo 288328289 Fernanda Carrasco | Dreamstime.com