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Collagen and Fibroblast Activity It appears to enhance fibroblast migration and collagen organization, which are essential for tendon and ligament healing. 3
383,384 Importantly, the activation of AMPK reduces the expression of phosphoglycerate mutase 5 (PGAM5), which plays a promotive role in cell necrosis by contributing to mitochondrial dysfunction and the production of reactive oxygen species (ROS)
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