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The different ones GI discontinuation rate: 5.6% of semaglutide (Wegovy) users stopped due to GI side effects, vs 2.7% of Tirzepatide (Mounjaro) users Diarrhoea: Common with Mounjaro because of its dual action Nausea and constipation: Seen more in Wegovy MHRA NAION warning (February 2026) : Both medications carry an updated warning about a very rare but serious eye condition (non-arteritic anterior ischaemic optic neuropathy)
Wang D, et al
For example, a prospective cohort study patients found that participants with higher IGF-1 levels had a 55% lower relative risk of myocardial infarction compared to those with lower levels (Macvanin et al., 2023)
These added benefits often improve overall metabolic health
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